FDA OKs Ariad’s drug for two rare blood cancers

(Reuters) – The U.S. Food and Drug Administration said on Friday it approved Ariad Pharmaceuticals Inc‘s drug to treat two rare types of blood cancer, three months ahead of the review date.

Iclusig was approved to treat chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia.

The drug, generically known as ponatinib, is being granted an orphan product status, intended for drugs that aim to treat rare diseases.

The FDA said that Iclusig was approved under its accelerated approval program, which provides patients earlier access to promising new drugs while the company conducts additional studies.

Orphan drug designation is granted by the health regulator to drugs or biologics that treat a condition affecting less than 200,000 Americans.

The status grants the drugmaker a marketing exclusivity of seven years in the United States, upon approval.

Iclusig, which blocks certain proteins that stimulate the development of cancer cells, was to be reviewed by the FDA on March 27. (http://link.reuters.com/vut64t)

(Reporting By Vrinda Manocha in Bangalore; Editing by Maju Samuel)

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UPDATE 3-Cricket-Hughes shines as Australia reach 299-4

* Hughes falls just short of century

* Clarke and Hussey combine for 101

* Welegedera takes 3-99 (Adds quotes)

HOBART, Dec 14 (Reuters) – Phil Hughes made a solid 86 on his return to test cricket before Michael Clarke and Mike Hussey took up the running and steered Australia to 299 for four at close of play on the first day of the first test against Sri Lanka on Friday.

Hughes was the only batsmen to fall in the final session, lasting only a couple of overs after lunch before being bowled through the gate by Chanaka Welegedera, giving the Sri Lankan seamer his third wicket of the day.

Clarke, who had made 70 not out, and Hussey, unbeaten on 37, batted through the remainder of the day and if the evidence of their prolific partnerships in the recent series against South Africa is anything to go by, will take some shifting.

“Overall, 299 for four puts the ball in our court,” said Hughes. “I thought we were outstanding today. It really gives us momentum going into tomorrow.”

Sri Lanka’s bowlers, dubbed this week as the worst pace attack ever to tour Australia by former test bowler Rodney Hogg, made life uncomfortable for the batsmen at times but struggled for any real penetration under cloudy skies at Bellerive Oval.

“I think we showed we can put Australia under pressure and hopefully the bowlers will be fresh in the morning and we can get them out for less than 100 additional runs,” said Welegedera, who finished with 3-99 on his return after nine months out injured.

Clarke, who passed 1,400 runs for the year, has now put on 731 runs in partnerships with Hussey in the last four tests and will be looking to plunder a few more on Saturday despite taking a couple of painful knocks to his legs.

Friday, however, belonged to Hughes.

The lefthander was recalled to the side on the back of good domestic form following the retirement of Ricky Ponting at the end of the series against the Proteas.

The 24-year-old reached his fourth test half century with a square drive for three runs and then initially accelerated towards a century, most notably with an ugly but effective slog for six off spinner Rangana Herath.

CALAMITOUS RUNOUT

On the ground where his second spell as a test batsman ended amid questions about his technique after two failures against New Zealand last year, Hughes scored eight fours and one six in his 166-ball knock before Welegedera struck with a superb ball.

“It was nice to get a few,” he said. “It would have been nice to get a few more and get into three figures.”

Australia had lost openers Ed Cowan (four) and David Warner in the opening session, the latter run out for 57 on the stroke of lunch after a calamitous misunderstanding with Hughes.

Shane Watson, dropping down to fourth in the batting order to allow Hughes to come in at number three, followed them to the pavilion for 30 shortly before tea, the victim of an exceptional diving catch in the slips by skipper Mahela Jayawardene.

That was a second wicket for Welegedera and a measure of redemption for the bowler after he had Hughes caught behind for 77 only for the umpire to call a no ball.

Welegedera had also made the early breakthrough for the tourists when Cowan tried to pull a short delivery only for the ball to catch him high on the bat and carry to mid-on where Shaminda Eranga took a simple catch.

It could have been even better for the Sri Lankans, who were only centimetres away from the perfect start to the morning after Clarke had won the toss and elected to bat.

Cowan edged the second delivery of the day from Nuwan Kulasekara to the slips but Angelo Mathews was just unable to get his hands to it, despite an athletic dive. (Editing by Peter Rutherford)

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TLC’s “Best Funeral Ever” runs Reality TV into the ground

LOS ANGELES (TheWrap.com – TLC, which brought the world “Here Comes Honey Boo Boo” and “Sister Wives,” has hit new depths: The new one-hour special “Best Funeral Ever” will follow dead people’s journey to the grave.

The network announced Thursday that “Best Funeral Ever” will focus on the Golden Gate Funeral Home in Dallas, which prides itself on its unique theme funerals – or as Golden Gate calls them, “home-going celebrations.”

“A home-going is much different than a funeral, it’s a celebration,” Golden Gate CEO John Beckwith Jr. says of his company’s approach. “The Golden Gate experience is our version of the traditional African American home-going celebration. We do not produce generic funerals; everybody’s experience has to be different.”

In the case of “Best Funeral Ever,” that includes a Christmas-inspired funeral complete with elves, reindeer and snow and a barbecue-themed sendoff for a doo-wop singer who was well-known for a rib sauce jingle. A State Fair-themed funeral will allow a man whose disabilities prevented him from riding roller coasters to finally, um, experience the thrill rides, games and attractions he missed out on in life. (Sounds like a great sequel to “Weekend at Bernie’s.”)

“Best Funeral Ever,” which is produced by Park Slope Productions, will premiere December 26 at 8 p.m. – just in case you’re experiencing any residual Christmas cheer and need a reminder of your mortality.

TV News Headlines – Yahoo! News

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Aides: Chavez in tough fight, may miss swearing-in

CARACAS, Venezuela (AP) — Somber confidants of President Hugo Chavez say he is going through a difficult recovery after cancer surgery in Cuba, and one close ally is warning Venezuelans that their leader may not make it back for his swearing-in next month.

Information Minister Ernesto Villegas said Wednesday night that Chavez was in “stable condition” and was with close relatives in Havana. Reading a statement, he said the government invites people to “accompany President Chavez in this new test with their prayers.”

Villegas expressed hope about the president returning home for his Jan. 10 swearing-in for a new six-year term, but said in a written message on a government website that if Chavez doesn’t make it, “our people should be prepared to understand it.”

Villegas said it would be irresponsible to hide news about the “delicateness of the current moment and the days to come.” He asked Venezuelans to see Chavez’s condition as “when we have a sick father, in a delicate situation after four surgeries in a year and a half.”

Moving to prepare the public for the possibility of more bad news, Vice President Nicolas Maduro looked grim when he acknowledged that Chavez faced a “complex and hard” process after his latest surgery.

At the same time, officials sought to show a united front amid the growing worries about Chavez’s health and Venezuela’s future. Key leaders of Chavez’s party and military officers appeared together on television as Maduro gave updates on Chavez’s condition.

“We’re more united than ever,” said Maduro, who was flanked by National Assembly President Diosdado Cabello and Oil Minister Rafael Ramirez, both key members of Chavez’s inner circle. “We’re united in loyalty to Chavez.”

Analysts say Maduro could eventually face challenges in trying to hold together the president’s diverse “Chavismo” movement, which includes groups from radical leftists to moderates, as well as military factions.

Tapped by the 58-year-old president over the weekend as his chosen political heir, Maduro is considered to be a member of radical left wing of Chavez’s movement that is closely aligned with Cuba’s communist government.

Cabello, a former military officer who also wields power within Chavez’s movement, shared the spotlight with Maduro by speaking at a Mass for Chavez’s health at a military base.

Just returned from being with Chavez for the operation, Cabello called the president “invincible” but said “that man who is in Havana … is fighting a battle for his life.”

After Chavez’s six-hour operation Tuesday, Venezuelan television broadcast religious services where people prayed for Chavez, interspersed with campaign rallies for upcoming gubernatorial elections.

On the streets of Caracas, people on both sides of the country’s deep political divide voiced concerns about Chavez’s condition and what might happen if he died.

At campaign rallies ahead of Sunday’s gubernatorial elections, Chavez’s candidates urged Venezuelans to vote for pro-government candidates while they also called for the president to get well.

“Onward, Commander!” gubernatorial candidate Elias Jaua shouted to a crowd of supporters at a rally Wednesday. Many observers said it was likely Chavez’s candidates could get a boost from their supporters’ outpouring of sympathy for Chavez.

Opposition leader Henrique Capriles, who lost to Chavez in the October presidential election and is running against Jaua, complained Wednesday that Chavez’s allies are taking advantage of the president’s health problems to try to rally support. He took issue with Jaua’s statement to supporters that “we have to vote so that the president recovers.”

Maduro looked sad as he spoke on television, his voice hoarse and cracked at times after meeting in the pre-dawn hours with Cabello and Ramirez. The pair returned to Venezuela about 3 a.m. after accompanying Chavez to Cuba for his surgery.

“It was a complex, difficult, delicate operation,” Maduro said. “The post-operative process is also going to be a complex and hard process.”

Without giving details, Maduro reiterated Chavez’s recent remarks that the surgery presented risks and that people should be prepared for any “difficult scenarios.”

The constitution says presidents should be sworn in before the National Assembly, and if that’s not possible then before the Supreme Court.

Former Supreme Court magistrate Roman Duque Corredor said a president cannot delegate the swearing-in to anyone else and cannot take the oath of office outside Venezuela. A president could still be sworn in even if temporarily incapacitated, but would need to be conscious and in Venezuela, Duque told The Associated Press.

If a president-elect is declared incapacitated by lawmakers and is unable to be sworn in, the National Assembly president would temporarily take charge of the government and a new presidential vote must be held within 30 days, Duque said.

Chavez said Saturday that if an election had to be held, Maduro should be elected president.

The dramatic events of this week, with Chavez suddenly taking a turn for the worse, had some Venezuelans wondering whether they were being told the truth because just a few months ago the president was running for his fourth presidential term and had said he was free of cancer.

Lawyer Maria Alicia Altuve, who was out in bustling crowds in a shopping district of downtown Caracas, said it seemed odd how Maduro wept at a political rally while talking about Chavez.

“He cries on television to set up a drama, so that people go vote for poor Chavez,” Altuve said. “So we don’t know if this illness is for that, or if it’s that this man is truly sick.”

Some Chavez supporters said they found it hard to think about losing the president and worried about the future. His admirers held prayer vigils in Caracas and other cities this week, holding pictures and singing hymns.

Chavez has undergone four cancer-related surgeries since June 2011. He has also undergone months of chemotherapy and radiation treatments. Throughout his treatments, Chavez has kept secret some details of his illness, including the exact location and type of the tumors.

Ecuadorean President Rafael Correa wished his close ally the best, while also acknowledging the possibility that cancer might end his presidency. “Chavez is very important for Latin America, but if he can’t continue at the head of Venezuela, the processes of change have to continue,” Correa said at a news conference in Quito.

___

Associated Press writer Christopher Toothaker contributed to this report.

Latin America News Headlines – Yahoo! News

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Selling flak jackets in the cyberwars

SAN FRANCISCO (Reuters) – When the Israeli army and Hamas trade virtual blows in cyberspace, or when hacker groups like Anonymous rise from the digital ether, or when WikiLeaks dumps a trove of classified documents, some see a lawless Internet.

But Matthew Prince, chief executive at CloudFlare, a little-known Internet start-up that serves some of the Web’s most controversial characters, sees a business opportunity.

Founded in 2010, CloudFlare markets itself as an Internet intermediary that shields websites from distributed denial-of-service, or DDoS, attacks, the crude but effective weapon that hackers use to bludgeon websites until they go dark. The 40-person company claims to route up to 5 percent of all Internet traffic through its global network.

Prince calls his company the “Switzerland” of cyberspace – assiduously neutral and open to all comers. But just as companies like Twitter, YouTube and Facebook have faced profound questions about the balance between free speech and openness on the Internet and national security and law enforcement concerns, CloudFlare‘s business has posed another thorny question: what kinds of services, if any, should an American company be allowed to offer designated terrorists and cyber criminals?

CloudFlare’s unusual position at the heart of this debate came to the fore last month, when the Israel Defense Forces sought help from CloudFlare after its website was struck by attackers based in Gaza. The IDF was turning to the same company that provides those services to Hamas and the al-Quds Brigades, according to publicly searchable domain information. Both Hamas and al-Quds, the military wing of the Palestinian Islamic Jihad, are designated by the United States as terrorist groups.

Under the USA Patriot Act, U.S. firms are forbidden from providing “material support” to groups deemed foreign terrorist organizations. But what constitutes material support – like many other facets of the law itself – has been subject to intense debate.

CloudFlare’s dealings have attracted heated criticism in the blogosphere from both Israelis and Palestinians, but Prince defended his company as a champion of free speech.

“Both sides have an absolute right to tell their story,” said Prince, a 38-year old former lawyer. “We’re not providing material support for anybody. We’re not sending money, or helping people arm themselves.”

Prince noted that his company only provides defensive capabilities that enable websites to stay online.

“We can’t be sitting in a role where we decide what is good or what is bad based on our own personal biases,” he said. “That’s a huge slippery slope.”

Many U.S. agencies are customers, but so is WikiLeaks, the whistle-blowing organization. CloudFlare has consulted for many Wall Street institutions, yet also protects Anonymous, the “hacktivist” group associated with the Occupy movement.

Prince‘s stance could be tested at a time when some lawmakers in the United States and Europe, armed with evidence that militant groups rely on the Web for critical operations and recruitment purposes, have pressured Internet companies to censor content or cut off customers.

Last month, conservative political lobbies, as well as seven lawmakers led by Ted Poe, a Republican from Texas, urged the FBI to shut down the Hamas Twitter account. The account remains active; Twitter declined to comment.

MATERIAL SUPPORT

Although it has never prosecuted an Internet company under the Patriot Act, the government’s use of the material support argument has steadily risen since 2006. Since September 11, 2001, more than 260 cases have been charged under the provision, according to Fordham Law School’s Terrorism Trends database.

Catherine Lotrionte, the director of Georgetown University’s Institute for Law, Science and Global Security and a former Central Intelligence Agency lawyer, argued that Internet companies should be more closely regulated.

“Material support includes web services,” Lotrionte said. “Denying them services makes it more costly for the terrorists. You’re cornering them.”

But others have warned that an aggressive government approach would have a chilling effect on free speech.

“We’re resurrecting the kind of broad-brush approaches we used in the McCarthy era,” said David Cole, who represented the Humanitarian Law Project, a non-profit organization that was charged by the Justice Department for teaching law to the Kurdistan Workers’ Party, which is designated by the United States as a terrorist group. The group took its case to the Supreme Court but lost in 2010.

The material support law is vague and ill-crafted, to the point where basic telecom providers, for instance, could be found guilty by association if a terrorist logs onto the Web to plot an attack, Cole said.

In that case, he asked, “Do we really think that AT&T or Google should be held accountable?”

CloudFlare said it has not been contacted about its services by the U.S. government. Spokespeople for Hamas and the Palestinian Islamic Jihad, told Reuters they contracted a cyber-security company in Gaza that out-sources work to foreign companies, but declined to comment further. The IDF confirmed it had hired CloudFlare, but declined to discuss “internal security” matters.

CloudFlare offers many of its services for free, but the company says websites seeking advanced protection and features can see their bill rise to more than $ 3,000 a month. Prince declined to discuss the business arrangements with specific customers.

While not yet profitable, CloudFlare has more than doubled its revenue in the past four months, according to Prince, and is picking up 3,000 new customers a month. The company has raked in more than $ 22 million from venture capital firms including New Enterprise Associates, Venrock and Pelion Venture Partners.

Prince, a Midwestern native with mussed brown hair who holds a law degree from the University of Chicago, said he has a track record of working on the right side of the law.

A decade ago, Prince provided free legal aid to Spamhaus, an international group that tracked email spammers and identity thieves. He went on to create Project Honey Pot, an open source spam-tracking endeavor that turned over findings to police.

Prince’s latest company, CloudFlare, has been hailed by groups such as the Committee to Protect Journalists for protecting speech. Another client, the World Economic Forum, named CloudFlare among its 2012 “technology pioneers” for its work. But it also owes its profile to its most controversial customers.

CloudFlare has hosted 4Chan, the online messaging community that spawned Anonymous. LulzSec, the hacker group best known for targeting Sony Corp, is another customer. And since last May, the company has propped up WikiLeaks after a vigilante hacker group crashed the document repository.

Last year, members of the hacker collective UgNazi, whose exploits include pilfering user account information from eBay and crashing the CIA.gov website, broke into Prince’s cell phone and email accounts.

“It was a personal affront,” Prince said. “But we never kicked them off either.”

Prince said CloudFlare would comply with a valid court order to remove a customer, but that the Federal Bureau of Investigation has never requested a takedown. The company has agreed to turn over information to authorities on “exceedingly rare” occasions, he acknowledged, declining to elaborate.

“Any company that doesn’t do that won’t be in business long,” Prince said. But in an email, he added: “We have a deep and abiding respect for our users’ privacy, disclose to our users whenever possible if we are ordered to turn over information and would fight an order that we believed was not proper.”

Juliannne Sohn, an FBI spokeswoman, declined to comment.

Michael Sussmann, a former Justice Department lawyer who prosecuted computer crimes, said U.S. law enforcement agencies may in fact prefer that the Web’s most wanted are parked behind CloudFlare rather than a foreign service over which they have no jurisdiction.

Federal investigators “want to gather information from as many sources as they can, and they’re happy to get it,” Sussmann said.

In an era of rampant cyber warfare, Prince acknowledged he is something of a war profiteer, but with a wrinkle.

“We’re not selling bullets,” he said. “We’re selling flak jackets.”

(Reporting By Gerry Shih in San Francisco and Nidal al-Mughrabi in Gaza; editing by Jonathan Weber and Claudia Parsons)

Internet News Headlines – Yahoo! News

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“Lincoln” leads Golden Globe movie nominations

LOS ANGELES (Reuters) – “Lincoln,” the tale of U.S. President Abraham Lincoln‘s battle to end slavery, ruled at the Golden Globe nominations on Thursday, while a very different movie take on slavery – “Django Unchained” – got a big boost in Hollywood’s crowded awards season.

Steven Spielberg’s portrayal of one of America’s most revered presidents won a leading seven nominations, including best drama, best director, best screenplay and best actor for Daniel Day-Lewis in the title role.

But “Lincoln” faces stiff competition at the Golden Globes from Ben Affleck’s Iran hostage drama “Argo” and Quentin Tarantino‘s dark and quirky slavery-era Western, “Django Unchained.”

The best drama nominees were rounded out by thriller “Zero Dark Thirty” about the hunt for Osama bin Laden, with four mentions, and the shipwreck tale, “Life of Pi,” with three.

The Golden Globe Awards, which will be given out by about 80 members of the Hollywood Foreign Press Association (HFPA) on January 13, are among the most widely watched honors programs leading up to the Oscars in February, although their ultimate choices for best movie rarely coincide.

‘LINCOLN’ SEEN AS OSCAR FRONTRUNNER

“Lincoln” is already regarded as an Oscar frontrunner after picking up multiple accolades from U.S. critics’ groups and the Screen Actors Guild (SAG).

Producer Kathleen Kennedy said the film’s portrayal of Lincoln’s battles in Congress to get slavery abolished had struck a chord with Americans at a time of political gridlock in Washington.

“People have become frustrated with the political process, and the movie takes you on a journey that shows the democratic process is difficult but the end result is a very satisfying process…I think that’s what people are excited about after watching ‘Lincoln,’” Kennedy told Reuters on Thursday.

Tarantino’s violent and sometimes comic “Django Unchained,” starring Jamie Foxx, has fared less well – until now.

“This was a huge boost. ‘Django Unchained‘ was very much SAG snubbed. But now they are really back in the game,” Thelma Adams, contributing editor at Yahoo! Movies, told Reuters.

“It’s very gratifying to get this many nominations from the HFPA for a film I worked so hard on and am so passionate about,” Tarantino said in a statement.

Unlike the Academy Awards, the HFPA has separate categories for film dramas and comedies.

“Les Miserables,” the movie version of the worldwide hit stage musical, earned four Golden Globe nominations in the comedy/musical category, as did “Silver Linings Playbook,” about an unlikely romance between a man suffering from bipolar disorder and a young widow.

The stars of both films – Hugh Jackman and Anne Hathaway for “Les Miserables,” and Jennifer Lawrence and Bradley Cooper for “Silver Linings Playbook,” – will be among those competing for acting awards.

FROM STAGE TO SCREEN

“Les Mis” director, Tom Hooper, who failed to get a nomination for his work on the movie, acknowledged the challenge of translating the beloved musical to the big screen.

“Millions of people hold this musical so close to their heart. I had to make a film that honors that experience…and I needed to find a way to work, which is why I chose to do all live singing,” Hooper told Reuters.

The HFPA also opened the door to smaller, sometimes overlooked movies and performances, while largely snubbing high profile contenders such as the James Bond film “Skyfall,” which got just one mention, for Adele’s best original song.

Wes Anderson’s “Moonrise Kingdom” and admired British senior ensemble film, “The Best Exotic Marigold Hotel,” were both nominated in the best musical or comedy category.

“They are precious little films that now have to be taken seriously,” said Tom O’Neil of awards website Goldderby.com.

In the acting race, Jessica Chastain’s CIA agent in “Zero Dark Thirty” will square off against Helen Mirren in “Hitchcock,” British actress Rachel Weisz in period drama, “The Deep Blue Sea,” France’s Marion Cotillard for “Rust and Bone,” and Naomi Watts in tsunami survival tale “The Impossible.”

Chastain said that aside from being a true-life thriller, “Zero Dark Thirty” also aimed at asking questions about society.

“To be involved in a movie that does that – the 9/11 hunt for Osama bin Laden pretty much defined this decade for us – and to be playing the woman who sacrificed so much to find him is such an honor,” the actress told Reuters.

Day-Lewis’s performance as Lincoln will compete against Denzel Washington’s alcoholic airline pilot in “Flight,” Richard Gere’s role as a corrupt financial executive in “Arbitrage,” John Hawkes as a severely disabled man in “The Sessions,” and Joaquin Phoenix’s drifter in the cult tale, “The Master.”

The Golden Globes also honor the year’s best TV shows. “Game Change,” the HBO film about Sarah Palin’s 2008 bid to become U.S. vice-president, led the nominations with five, followed by post-9/11 psychological thriller, “Homeland,” with four.

(Additional reporting by Piya Sinha-Roy and Eric Kelsey; Editing by Paul Simao and David Brunnstrom)

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In challenge to personalized cancer care, DNA isn’t all-powerful

NEW YORK (Reuters) – The cancer cells were not behaving the way the textbooks say they should. Some of the cells in colonies that were started with colorectal tumor cells were propagating like mad; others were hardly multiplying. Some were dropping dead from chemotherapy and others were no more slowed by the drug than is a tsunami by a tissue. Yet the cells in each “clone” all had identical genomes, supposedly the all-powerful determinant of how cancer cells behave.

That finding, published online Thursday in Science, could explain why almost none of the new generation of “personalized” cancer drugs is a true cure, and suggests that drugs based on genetics alone will never achieve that holy grail.

Scientists not involved in the study praised it for correcting what Dr. Charis Eng, an oncologist and geneticist who leads the Genomic Medicine Institute at the Cleveland Clinic, called “the simple-minded” idea that tumor genomes alone explain cancer.

Calling the study “very exciting,” she said the finding underlines that a tumor’s behavior and, most important, its Achilles heel depend on something other than its DNA. Her own work, for instance, has shown that patients with identical mutations can have different cancers.

The core premise of the leading model of cancer therapy is that cells become malignant when they develop mutations that make them proliferate uncontrolled. Find a molecule that targets the “driver” mutation, and a pharmaceutical company will have a winner and patients will be cancer-free.

That’s the basis for “molecularly targeted” drugs such as Pfizer’s Xalkori for some lung cancers and Novartis’s Gleevec for chronic myeloid leukemia. When those drugs stop working, the dogma says, it is because cells have developed new cancer-causing mutations that the drugs don’t target.

In the new study, however, scientists found that despite having identical genetic mutations, colorectal cancer cells behaved as differently as if they were genetic strangers. The findings challenge the prevailing view that genes determine how individual cells in a solid tumor behave, including how they respond to chemotherapy and how actively they propagate.

If DNA is not the sole driver of tumors’ behavior, said molecular geneticist John Dick of the Princess Margaret Cancer Centre in Toronto, who led the study, it suggests that, to vanquish a cancer entirely, drugs will have to target their non-genetic traits too, something few drug-discovery teams are doing.

Genomes are what cutting-edge clinics test for when they try to match a patient’s tumor to the therapy most likely to squelch it.

For their study, Antonija Kreso, Catherine O’Brien and other scientists under Dick’s direction took colorectal cancer cells from 10 patients and transplanted them into mice. They infected the cells with a special virus that let them track each cell, even after it divided and multiplied and was transplanted into another mouse, then another and another, through as many as five such “passages.”

Only one in 10,000 tumor cells was responsible for keeping the cancer growing, the scientists found – in some cases for 500 days of repeated transplantation from one mouse to the next. Genetically-identical tumor cells stopped dividing within 100 days even without treatment.

Tumor cells that were not killed by chemotherapy – the scientists used oxaliplatin, a colon-cancer drug sold by Sanofi as Eloxatin – had the same mutations as cells that were. The survivors tended to be dormant, non-proliferating ones that suddenly became activated, causing the tumor to grow again. Yet the cells – dormant or active, invulnerable to chemo or susceptible – had identical genomes.

“I thought we’d be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference,” said Dick. “That goes against a main dogma of the cancer enterprise: that if a tumor comes back after treatment it’s because some cells acquired mutations that made them resistant.”

That’s true in some cases, he said, “but what our data are saying is, there are other biological properties that matter. Gene sequencing of tumors is definitely not the whole story when it comes to identifying which therapies will work.”

The results were surprising enough, Dick said, that experts reviewing the paper for Science asked him to run additional tests to make sure the cells that behaved so differently were in fact genetic twins. He did, they were, and Science accepted the paper.

Other experts also praised the work, saying it supported the growing suspicion in the field that personalized cancer therapy is oversimplistic, at least in how it’s sold to the public.

“It’s not as simple as just sequencing mutations to tailor therapies to each tumor,” said surgical oncologist Dr. Steven Libutti of the Montefiore Einstein Center for Cancer Care in New York City. “In my mind, the findings are not unexpected. Other things besides genes matter: the environment in which a tumor is growing, for instance, plays an important role in whether therapy will be effective.”

Rather than targeting DNA alone, the Toronto scientists suspect, effective therapies would also take aim at what phase of its cycle a cell is in (dormant, growing or dividing, for example), which of its genes are activated, whether it sits in a region of the tumor that is starved of oxygen, and other non-genetic properties.

Nudging tumor cells out of their dormant phase and into their growth cycles, for instance, could make them more susceptible to chemotherapy, which generally targets rapidly dividing cells.

“Our findings raise questions about the resources put into sequence, sequence, sequence,” said Dick. “That has led to one kind of therapeutic” – molecularly-targeted drugs – “but not the cures the public is being promised.”

(Reporting by Sharon Begley; editing by Claudia Parsons)

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GOP losing public opinion wars in debt talks

WASHINGTON (Reuters) - Negotiations are expected to continue Thursday on the "fiscal cliff" with Republicans at a growing public opinion disadvantage and approval ratings for President Barack Obama rising to levels not seen since the killing of Osama bin Laden.

Senior Democratic Senator Kent Conrad of North Dakota said on MSNBC late Wednesday that he thought Obama and House of Representatives Speaker John Boehner were edging closer to a deal.

He added that he hoped something will be announced next week to avert the steep tax hikes and budget cuts set for the start of 2013.

"I believe that they will have a framework agreement," Conrad said. "I believe they'll have it early next week. And I believe it will secure the votes in both the Senate and the House. We may miss some on the wings, but I think the center will hold."

Republican Representative Kevin Brady of Texas, in a Fox Business News interview Wednesday evening, disagreed with Conrad's assessment.

"I started pretty optimistic about this that we could get this done well before the holidays, but I don't feel that way anymore," Brady said. "It seems to me a decision's been made perhaps by the White House already to take us off this fiscal cliff."

Conservative Republican Senator Jim DeMint of South Carolina said the economy had already been damaged by the uncertainty caused by the deadlock.

"We can't fix it Christmas Eve and expect it all to bounce back in January," he said Thursday on CBS.

Sharp differences remained between congressional Republicans and the White House in talks to avert the cliff, and negotiators warned the showdown could drag on past Christmas.

Both sides refused to give any ground in public, with the main sticking point being the expiring tax cuts, which Obama wants extended for all but high earners and Boehner wants extended for everyone.

Polling shows strong support for Obama's position. According to a Wall Street Journal/NBC survey released late Wednesday, three-quarters of Americans say they would accept raising taxes on the wealthy to avoid the cliff.

Among Republicans, some 61 percent say they would accept tax increases on high earners.

An ABC News-Washington Post poll released Tuesday indicted that nearly half of Americans approve of Obama's handling of the negotiations versus the quarter of respondents who approved of Boehner's.

At the same time, Obama's public opinion rating has reached about 54 percent in the Real Clear Politics polling average, above the level where it peaked in May 2011, when bin Laden was killed.

Republicans are in a bad negotiating position, Conrad said, noting that the Democratic-controlled Senate has already passed a bill preserving tax cuts for the middle-class, leaving the Republican-controlled House standing in the way.

"And so Republicans are really in an awkward position," he said.

Boehner, meanwhile, faces increasingly conflicting pressures, from the right to hold firm, from the Republican center to be flexible and from the polls to abandon his position.

(Editing by Xavier Briand)

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Review: PlayStation icons join in ‘Battle Royale’

The holiday season is a good time to catch up with old friends. If you’re an Xbox fan, you’re probably getting reacquainted with galactic warrior Master Chief in his new adventure, “Halo 4.” If you’re a Nintendophile, you’re probably frolicking with Mario on your new Wii U.

Sony, meanwhile, has expanded its holiday guest list to invite nearly two decades worth of characters to mix it up in “PlayStation All-Stars Battle Royale” (for the PlayStation 3, $ 59.99; Vita, $ 39.99). Fans of the original PlayStation can welcome back old pals like Sir Daniel Fortesque of “MediEvil” and the title character of “Parappa the Rapper.” Younger gamers who have only known the PS3 will be happy to see Nathan Drake from “Uncharted” and Cole MacGrath from “Infamous.” Turn them loose in an assortment of game-inspired arenas and you’ve got chaos.

It’s not an original idea: Nintendo has been pitting its lovable characters against each other since 1999′s “Super Smash Bros.” As you’d expect, “All-Stars” lets up to four players choose their favorite personalities and pound on each other until one is left standing.

The technique is a change from most fighting games. Most of the time, kicking or punching your opponent doesn’t do much damage. Instead, each blow adds to an attack meter; build up enough energy and you can unleash three levels of truly deadly moves. There’s a little more strategy, but most players won’t find it too complicated.

The solo campaign is awfully skimpy, but “All-Stars” makes for a lively party when you have a few friends over. Two-and-a-half stars out of four.

— Sony’s burlap-clad goofball Sackboy is part of the “All-Stars” lineup, but he takes center stage in “LittleBigPlanet Karting” ($ 59.99).

Yes, it’s a go-kart racer — a genre that has already made room for Mario, Donkey Kong and Sonic the Hedgehog — but Sony freshens it up by giving you the ability to build your own racetracks and share them online. By exploring the game’s built-in courses, you can find hundreds of elements to add to your own, and they all share the homespun “arts-and-crafts” aesthetic of the original “LittleBigPlanet.”

Unfortunately, “LBP Karting” also revives the weird, floaty physics of its parent. That worked fine in the two-dimensional fantasy world of “LBP,” but it’s annoying when you’re behind the wheel. The tracks are filled with the power-ups, obstacles and gravity-defying leaps you’d expect in a kart racer, but the vehicles themselves feel sluggish and unresponsive. Two stars.

—Insomniac Games’ popular “lombax”-robot buddies are celebrating their 10th anniversary, both in “All-Stars” and their own “Ratchet & Clank: Full Frontal Assault” ($ 19.99). The latter game, however, is a big disappointment, stripping away most of what made the team so endearing.

It’s a “base defense” game, meaning you’re plopped down on a planet and then have to protect your turf from waves of invading enemies. That eliminates the exploration and discovery that made most of the “R&C” games so absorbing, replacing it with a tiresome cycle of building fortifications, having them destroyed, then rebuilding them. Instead of the comedy that was once this series’ trademark, you get drudgery. One star.

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Follow Lou Kesten on Twitter at http://twitter.com/lkesten

Gaming News Headlines – Yahoo! News

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Why Hillary Clinton won't get a break from public life

By Walter Shapiro

The envelope, please. The 2012 award for the most candid comment by a prominent public official goes to Hillary Clinton. Her uncharacteristic burst of honesty adds a layer of complexity to the premature speculation about her political future.

In an interview with the New York Times columnist Gail Collins, Clinton revealed her fantasy for 2013 after she takes her final globe-girdling flight as secretary of state: “I just want to sleep and exercise and travel for fun. And relax. It sounds so ordinary, but I haven’t done it for 20 years. I would like to see whether I can get untired.”

The dream seems so modest: to see whether her 65-year-old body can recover from years of too much stress and too little sleep. But Hillary Clinton, Private Citizen will soon have to confront the world clamoring at her door with its own set of expectations, requests and demands for clarity about running for president in 2016.

Friends who want her to speak, receive an award or grace a charitable event have been told to hold off asking until April or May, according to a front-page story in last Sunday’s Times by Jodi Kantor. As an indication of the coming news media frenzy, the New York Times is already lavishing more space on the whither-Hillary beat than the tabloids devote to Lindsay Lohan and Kate Middleton. Combined.

What this means, of course, is no rest for the weary and world-famous.

Sure, Clinton may take two months or so off, interspersed with such restful tasks as house-hunting (the Clintons are said to be tempted by the Hamptons), hiring a staff, talking to a lecture agent, contemplating a book and presumably chatting with the most persistent political callers. If she does manage to sneak off on a vacation (Iowa is always lovely in March), rest assured that the paparazzi and the political press will be close behind.

Try as she might, Clinton will find it difficult, if not impossible, to avoid being entangled in a web of obligation. Legions of friends (and, unlike the norm in politics, her longstanding friendships appear genuine) will ask her for time-consuming favors that cannot all be rejected. The do-gooder side of her nature will propel her into too many events and trips for worthy causes. And, as a Clinton, she knows all too well how easily political supporters bristle when their egos are not being stroked.

I first interviewed Hillary Clinton in the governor’s mansion in Little Rock in 1992. And since then, I have made my contributions to that mushrooming branch of journalism called Hillary Studies. This experience has left me with an appreciation for her complexity as a person—and a reluctance to assume that her only motivations are ambition and a feminist obligation to seize the opportunity to become the first woman president.

So I have no idea if she will run in 2016, and I doubt if she does either. Clinton’s State Department spokesman Philippe Reines got it right when he cautioned the Times, “Be very wary of those pretending to bear actual knowledge.” Over the next two years, everyone in politics could learn enough classical Greek to read “The Iliad” in the time that they will devote to devouring speculative articles built around anonymous quotes from “Clinton friends.”

If she does make another bid for the White House, Clinton will have been granted the ultimate luxury in presidential politics. And that is to take the time in advance to contemplate what she would want to accomplish in the White House rather than having to focus solely on the mechanics for getting there.

The only post-war presidents who have had a chance to think seriously about governing from the White House before they took office were Dwight Eisenhower, Richard Nixon and Ronald Reagan. And in politics, as in country music, two out of three ain’t bad.

Since Reagan in 1980, every new president simultaneously held a normally demanding day job (vice president, governor or senator) when he was elected. Bill Clinton, for example, rushed from a 1990 reelection campaign as Arkansas governor to a roller-coaster race for the White House to president-elect without a moment for reflection. And this careening from crisis to crisis contributed to Clinton’s disastrous first two years in the White House.

But with Hillary Clinton it could be different. She has the right instincts about what she wants to do with the long-awaited gift of free time. Reading something other than briefing books and classified memos would add to her already impressive breadth of her knowledge. Unstructured conversations with old friends and major thinkers might lead her in surprising intellectual directions. Such a laid-back interlude would make her, if elected, a better and more thoughtful president in 2017.

That is the theory. But the sad truth is that Hillary Clinton will never be allowed to go off the grid for long. Her celebrity is too great; the clamor for a piece of her political future is too intense.

So Clinton will dutifully do what is expected of her as a private citizen: attending an international conference in Bangladesh, holding an off-the-record meeting with potential political donors, writing a book, making a few policy addresses on national security. And someday, if she does return to the White House in 2017, she will still fantasize about being untired.

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